孟璇，博士，毕业于天津大学药物科学与技术学院，现任365bet，硕士生导师，现代产业学院教研室副主任，讲师。
科研领域及方向
以药剂学为学科基础，研究新型药物递送系统在疾病诊疗中的应用。
[1] 应答响应型药物递送系统
致力于肿瘤微环境调控的智能纳米药物递送系统，包括高分子纳米胶束、无机-有机杂化载体、脂质体、水凝胶等。
[2] 新型生物材料的研究
通过药学、化学、生物学、食品科学与纳米医学等手段，研究新型纳米材料在生物领域的应用，用于疾病防治与诊疗。
科研项目情况
[1] 国家自然科学基金青年项目：具有低皮肤光毒性的声动力学抗癌纳米递送系统，2022-2024；主持。
[2] 国家自然科学基金面上项目：应答型纳米载体增敏ACSL4缺失肿瘤细胞的程序性铁死亡研究，2020-2023；参与。
主要学术成果
致力于肿瘤微环境调控的智能纳米载体及刺激响应型生物材料的研究，以药剂学为背景依托，在调控肿瘤微环境、改善肿瘤细胞耐药性与氧自由基疗法增强抗肿瘤疗效等方面取得了一定的成果，已发表高水平论文10余篇，累计影响因子>100。发表的主要学术论文有：
1. Meng X, Deng J, Liu F, Guo T, Liu M, Dai P, Fan A, Wang Z, and Zhao Y. Triggered all-active metal organic framework: Ferroptosis machinery contributes to the apoptotic photodynamic antitumor therapy. Nano Letters, 2019, 19(11): 7866-7876. (SCI 1, Top journal, IF: 12.279)
2. Meng X, Wang L, Zhao N, Zhao D, Shen Y, Yao Y, Jing W, Man S, Dai Y, and Zhao Y. Stimuli-responsive cancer nanomedicines inhibit glycolysis and impair redox homeostasis. Acta Biomaterialia, 2023, 167: 374-386. (SCI 1, Top journal, IF: 10.688)
3. Meng X, Gao M, Deng J, Lu D, Fan A, Ding D, Kong D, Wang Z, and Zhao Y. Self-immolative micellar drug delivery: The linker matters. Nano Research, 2018, 11(12): 6177-6189. (SCI 1, Top journal, IF: 8.515)
4. Meng X, Liu H, Zhao N, Yang Y, Zhao K, and Dai Y. Molecular Dynamics Study of the Effect of Charge and Glycosyl on Superoxide Anion Distribution near Lipid Membrane. International Journal of Molecular Sciences, 2023, 24,10926. (SCI 2, Top journal, IF: 5.6)
5. Gao M#, Meng X#, Guo X, Zhu J, Fan A, Wang Z, and Zhao Y. All-active antitumor micelles via triggered lipid peroxidation. Journal of Controlled Release, 2018, 286: 381-393. (Co-first author; SCI 1, Top journal, IF: 7.901)
6. Li J#, Meng X#, Deng J, Lu D, Zhang X, Chen Y, Zhu J, Fan A, Ding D, Kong D, Wang Z, and Zhao Y. Multifunctional micelles dually responsive to hypoxia and singlet oxygen: enhanced photodynamic therapy via interactively triggered photosensitizer delivery. ACS Applied Materials & Interfaces, 2018, 10(20): 17117-17128. (Co-first author; SCI 1, Top journal, IF: 8.456)
7. Zhang S#, Meng X#, Wang Z, Fan A, Wang G, Zhao Y, and Tang Y. Engineering hot-melt extruded solid dispersion for controlled release of hydrophilic drugs. European Journal of Pharmaceutical Sciences, 2017, 100: 109-115. (Co-first author; SCI 2, IF: 3.532)
8. Lan X, Dai Y, Jing W, Meng X*, Liu F, Wang S, He A, and Li N. DFT investigation on the carbonate radical formation in the system containing carbon dioxide and hydroxyl free radical. Journal of Molecular Graphics and Modelling, 2022, 114, 108182. (SCI, corresponding author)
9. An Y, Zhu J, Liu F, Deng J, Meng X, Liu G, Wu H, Fan A, Wang Z and Zhao Y. Boosting the ferroptotic antitumor efficacy via site-specific amplification of tailored lipid peroxidation. ACS Applied Materials & Interfaces, 2019, 11(33): 29655-29666.
10. Yan Q, Guo X, Huang X, Meng X, Liu F, Dai P, Wang Z, and Zhao Y. Gated mesoporous silica nanocarriers for hypoxia-responsive cargo release. ACS Applied Materials & Interfaces, 2019, 11(27): 24377-24385.
11. Chen C, Zhao J, Gao M, Meng X, Fan A, Wang Z, and Zhao Y. Photo-triggered micelles: simultaneous activation and release of microtubule inhibitors for on-demand chemotherapy. Biomaterials Science, 2018, 6(3): 511-518.
12. Xin K, Li M, Lu D, Meng X, Deng J, Kong D, Ding D, Wang Z, and Zhao Y. Bioinspired coordination micelles integrating high stability, triggered cargo release, and magnetic resonance imaging. ACS Applied Materials & Interfaces, 2017, 9(1): 80-91.
13. Li M, Gao M, Fu Y, Chen C, Meng X, Fan A, Kong D, Wang Z, and Zhao Y. Acetal-linked polymeric prodrug micelles for enhanced curcumin delivery. Colloids and Surfaces B: Biointerfaces, 2016, 140: 11-18.
联系方式
办公地点：天津经济技术开发区第十三大街29号365bet
邮政编码：300457
办公电话：022-60601265
传 真：022-60602298
Email：mengxuan@tust.edu.cn
